Does the gut handling bacteria in an abnormal way lead to Crohn’s Disease

Project: Investigate the way in which the gut handles bacteria, and whether an abnormal way of dealing with bacteria leads to Crohn’s Disease

Year: 2015 – IN PROGRESS

Researcher: Dr Holm Uhlig, University of Oxford

Background:

IBD results from a dysregulated immune response towards to bacterial flora. Increasing evidence suggests that a form of innate deficiency to effectively clear translocated bacteria may underly at least some subsets of Crohn’s disease.

Aims: The ultimate aim is to develop therapies for IBD patients that do not necessarily function as immunosuppressive but to target bacteria handling defects.

donatehome1Anticipated Outcome:

We assume that intestinal granulomatous colitis in conventional multifactorial Crohn’s disease as well as Crohn’s disease like intestinal inflammation in monogenic (controlled by a single gene) disorders depend on shared mechanisms. We speculate that granuloma (small area of inflammation in tissue) in IBD is caused by intrinsically altered innate response mechanisms to inflammatory as well as bacterial challenges. We will aim to identify endogenous as well as exogenous stimuli that promote granuloma formation in Crohn’s disease.

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